Pulmonary toxicity of malaria prophylaxis.

Correspondence t Davidson. The increased use of malaria prophylaxis has led to more reports of drug induced toxicity. Hepatic, renal, skin, and bone marrow effects are well recognised. Five cases of pulmonary toxicity and systemic illness after the use of pyrimethamine-sulfadoxine (Fansidar) have been reported.'-' In two of these reports rapidly progressive respiratory failure developed and open lung biopsy showed eosinophilic pneumonia. We report four cases of pulmonary eosinophilia: three patients became ill after taking pyrimethaminedapsone (Maloprim; Wellcome) and one after taking pyrimethamine-chloroquine (Daraclor; Wellcome).